MDD with peripartum onset should be addressed concurrently with NICU and neonatal abstinence syndrome care.  The incidence of MDD with peripartum onset in mothers of babies in the NICU is much higher than those for mothers of infants in standard care and estimated at 28% to 70%.  There are a number of factors that affect the development of MDD with peripartum onset in mothers of NICU babies including grief, shame, loss, and lack of control.